Projects
at
Cardiovascular and Renal
Ongoing PhD projects
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Tone H. Østhus, MD
Health related Quality of Life (HRQOL) is known to be substantially suppressed in dialysis patients. Improved HRQOL in dialysis patients is suggested to improve medical outcomes, due to its relation with mortality, morbidity and hospitalization rates. The study is a national cohort that aims to describe HRQOL and factors that may significantly affect HRQOL in Norwegian dialysis patients. Clinical features, sleep issues and psychological factors will be investigated. By better understanding of HRQOL in dialysis patients and by seeking possible targets for interventions, this study also aims to built a base for future studies on causal relations. HRQOL associations with 1- and 5- year mortality is part of the present work.
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Helga Gudmundsdottir, MD
Helga Gudmundsdottir has re-examined hypetertensive and normotensive men after 20 years of follow-up. The aim is to study blood pressure development and how blood pressure, heart rate and plasma catecholamines predict the development of sympathetic activity through 20 years.
- Gernot Ernst, MD
Heart rate variability (HRV) has been used to assess changes in heart function and cardiac health. 1) In an observational study we will explore possible associations between HRV and long-term mortality after hip fractures. 2) We will test if there is an association between patients at an early stage of a systemic inflammatoric reaction (measured by SIRS criteria) and HRV. 3) Prognosis is still a challenge in palliative patients. We will test if HRV changes happen in the last months and weeks of life. 4) Sleep deprivation has influences on several body functions. Cardiologic diseases have been associated with night time workers. A study shall assess HRV-changes in night time-workers.
- Camilla Søraas Lund, MD
The aim of our study is to describe changes in the myocardium following coronary artery bypass grafting surgery. We hypothesize that myocardial perfusion and function improves rapidly after revascularization. The methods used are myocardial scintigraphy and echocardiography preoperatively, 2-4 days postoperatively and 6 weeks postoperatively.
- Anne Cecilie K. Larstorp, MD
The objective of the project is to investigate the prognostic value of regression of left ventricular hypertrophy in the electrocardiogram for various cardiovascular endpoints: non-fatal stroke, non-fatal MI, cardiovascular mortality, atrial fibrillation, heart failure and composite endpoints. The study population is a LIFE-subgroup with 1320 patients with isolated systolic hypertension.
- Skjalg Hasselund, MD
Antocyanins are powerful antioxydants, and the aim of the project is to examine whether treatment with antocyanins lower blood pressure in men with borderline hypertension. Furthermore, we want to assess the effect on the sympathoadrenal system, both during rest and stress tests.
Other research projects involving the Section of Cardiovascular and Renal Research
- Solbjørg Sagedal, MD, PhD, and Håvard Viko, MD, PhD, Department of Nephrology
Study on renal insufficiency.
- Ingjerd Manner, MD, Department of Infectious diseases and Department of Nephrology
HIV infection and kidney failure.
- Dialysis register, Department of Nephrology:
Registration
- Mohammad Hassan Abou-Arab, MD, Department of Anaestesiology, Oslo University Hospital, Ullevaal and Aker
Sympathetic responses to various anaestetic agents.
- SHARP study
- Løset, MD, NTNU, Trondheim
Sympathetic and serotonergic responses to hypoxia.